Argireline

Also known as: Acetyl Hexapeptide-3, Acetyl Hexapeptide-8

SNAP-25 mimetic peptide that inhibits SNARE complex formation, reducing neurotransmitter release at neuromuscular junctions; topical 'Botox alternative'.

Typical dose: 0 mcg
Frequency: twice daily
Route: Td
Half-life: 8 hours
Routes: Td
Status: Cosmetic ingredient: not FDA-regulated as drug

Track your Argireline protocol in Vial →

Benefits

Wrinkle reduction (topical)
Expression line softening
Non-invasive anti-aging
SNAP-25 modulation

Dosing

A common research range for Argireline is 0 mcg twice daily. TOPICAL ONLY: not injectable or oral. 5-10% serum; apply to wrinkle-prone areas. These figures are reference points from published literature, not a prescription — your protocol should be set with a licensed provider.

Half-life

Argireline has an approximate half-life of 8 hours. Vial can display informational half-life estimates when supported data is available. These estimates are not measured blood concentrations or dosing instructions.

Storage

Room temperature; away from direct sunlight.

Reported side effects

Skin irritation (rare)
Mild tingling on first use

Contraindications

Skin sensitivity to hexapeptides

Commonly stacked with

Snap-8 Matrixyl

Track Argireline with Vial

Vial logs every Argireline dose, organizes your schedule, and offers reconstitution math and supported half-life estimates. Tracking records stay on your device. A Vial Pro subscription is required. Download Vial on the App Store →

This page is for educational and harm-reduction purposes only. Argireline is not FDA-approved for most uses described here. Always consult a licensed physician before starting any peptide protocol. Vial does not sell peptides, recommend vendors, or provide medical advice.