Klotho

Also known as: α-Klotho, Anti-aging hormone

Endogenous longevity protein (transmembrane and soluble forms): modulates FGF23 signaling, oxidative stress, and Wnt pathways. Soluble Klotho declines with age and correlates with cognitive function. Note: Klotho is a protein hormone, not a small peptide: included alongside longevity peptides because of its biohacker prominence.

Frequency: once weekly
Route: Subcutaneous
Routes: Subcutaneous, Iv
Status: Investigational: no human therapeutic approval

Track your Klotho protocol in Vial →

Benefits

Cognitive preservation
Kidney protection
Anti-aging signaling
Insulin sensitivity

Dosing

Investigational; no standardized human dosing protocol: research only. These figures are reference points from published literature, not a prescription — your protocol should be set with a licensed provider.

Reconstitution

A typical reconstitution for Klotho is 1 mg of peptide in 1 mL of bacteriostatic water, giving roughly 1 mg per mL. Vial's built-in calculator works out the exact syringe draw for any vial size and dose.

Storage

2-8°C; sensitive to freeze-thaw.

Reported side effects

Unknown long-term profile
Theoretical risk of phosphate dysregulation

Contraindications

Phosphate metabolism disorders
Active malignancy

Commonly stacked with

Epithalon NAD+

Track Klotho with Vial

Vial logs every Klotho dose, plots its half-life curve, calculates reconstitution math, and keeps your whole protocol on schedule — on-device and private. Download Vial on the App Store →

This page is for educational and harm-reduction purposes only. Klotho is not FDA-approved for most uses described here. Always consult a licensed physician before starting any peptide protocol. Vial does not sell peptides, recommend vendors, or provide medical advice.