Matrixyl

Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS

Lipopeptide that stimulates collagen I, III, and IV synthesis plus fibronectin production; signals skin repair via TGF-β pathway activation.

Typical dose: 0 mcg
Frequency: twice daily
Route: Td
Half-life: 8 hours
Routes: Td
Status: Cosmetic ingredient

Track your Matrixyl protocol in Vial →

Benefits

Collagen synthesis stimulation
Wrinkle depth reduction
Skin firmness improvement
Synergy with retinol

Dosing

A common research range for Matrixyl is 0 mcg twice daily. TOPICAL ONLY: not injectable or oral. 2-5% in serum or moisturizer. These figures are reference points from published literature, not a prescription — your protocol should be set with a licensed provider.

Half-life

Matrixyl has an approximate half-life of 8 hours. Vial can display informational half-life estimates when supported data is available. These estimates are not measured blood concentrations or dosing instructions.

Storage

Room temperature.

Reported side effects

Generally well-tolerated
Mild redness on sensitive skin

Commonly stacked with

Argireline GHK-Cu

Track Matrixyl with Vial

Vial logs every Matrixyl dose, organizes your schedule, and offers reconstitution math and supported half-life estimates. Tracking records stay on your device. A Vial Pro subscription is required. Download Vial on the App Store →

This page is for educational and harm-reduction purposes only. Matrixyl is not FDA-approved for most uses described here. Always consult a licensed physician before starting any peptide protocol. Vial does not sell peptides, recommend vendors, or provide medical advice.