PE-22-28
Also known as: Spadin Analog
TREK-1 potassium channel blocker; antidepressant mechanism via inhibiting TREK-1 (a two-pore potassium channel linked to depression resistance).
- Typical dose
- 200 mcg – 1 mg
- Frequency
- once daily
- Route
- Subcutaneous
- Half-life
- 1.5 hours
- Routes
- Subcutaneous, Intranasal
- Status
- Research chemical
Benefits
- Rapid antidepressant effect
- Neurogenesis in hippocampus
- BDNF increase
- Works within days (not weeks)
Dosing
A common research range for PE-22-28 is 200 mcg to 1 mg once daily. Experimental; preclinical data only. These figures are reference points from published literature, not a prescription — your protocol should be set with a licensed provider.
Reconstitution
A typical reconstitution for PE-22-28 is 5 mg of peptide in 2 mL of bacteriostatic water, giving roughly 2.5 mg per mL. Vial's built-in calculator works out the exact syringe draw for any vial size and dose.
Half-life
PE-22-28 has an approximate half-life of 1.5 hours. Vial can display informational half-life estimates when supported data is available. These estimates are not measured blood concentrations or dosing instructions.
Storage
2-8°C post-reconstitution.
Reported side effects
- Unknown human profile
- Theoretical cardiac effects
Contraindications
- Cardiac arrhythmia
- Pregnancy
Commonly stacked with
Track PE-22-28 with Vial
Vial logs every PE-22-28 dose, organizes your schedule, and offers reconstitution math and supported half-life estimates. Tracking records stay on your device. A Vial Pro subscription is required. Download Vial on the App Store →
This page is for educational and harm-reduction purposes only. PE-22-28 is not FDA-approved for most uses described here. Always consult a licensed physician before starting any peptide protocol. Vial does not sell peptides, recommend vendors, or provide medical advice.