Pentosan Polysulfate
Also known as: PPS, Elmiron, Cartrophen
Glycosaminoglycan with chondroprotective, anti-inflammatory, and anticoagulant properties; supports cartilage matrix repair.
- Typical dose
- 100 mg – 150 mg
- Frequency
- twice weekly
- Route
- Subcutaneous
- Half-life
- 1 day
- Routes
- Subcutaneous, Intramuscular, Oral
- Status
- FDA-approved (oral) for interstitial cystitis
Benefits
- Joint and cartilage repair
- Interstitial cystitis relief
- Anti-inflammatory
- Stimulates proteoglycan synthesis
Dosing
A common research range for Pentosan Polysulfate is 100 mg to 150 mg twice weekly. These figures are reference points from published literature, not a prescription — your protocol should be set with a licensed provider.
Half-life
Pentosan Polysulfate has an approximate half-life of 1 day. Vial can display informational half-life estimates when supported data is available. These estimates are not measured blood concentrations or dosing instructions.
Storage
Room temperature.
Reported side effects
- Bruising at injection site
- Headache (rare)
- Macular changes (long-term oral)
Contraindications
- Active bleeding disorders
- Heparin sensitivity
Commonly stacked with
Track Pentosan Polysulfate with Vial
Vial logs every Pentosan Polysulfate dose, organizes your schedule, and offers reconstitution math and supported half-life estimates. Tracking records stay on your device. A Vial Pro subscription is required. Download Vial on the App Store →
This page is for educational and harm-reduction purposes only. Pentosan Polysulfate is not FDA-approved for most uses described here. Always consult a licensed physician before starting any peptide protocol. Vial does not sell peptides, recommend vendors, or provide medical advice.